Contents

Search

drug interaction(s) of statins with macrolide

Drug interactions: - macrolide taken together with a statin may raise plasma levels of statins & increase the risk for myopathy, including rhabdomyolysis - risk for erythromycin & clarithromycin is 2-fold that of azithromycin [1] - interaction via inhibition of CYP3A4 by macrolide

Properties

DRUGS: HMG CoA reductase inhibitor macrolide

References

  1. Patel AM et al Statin Toxicity From Macrolide Antibiotic Coprescription: A Population-Based Cohort Study. Ann Intern Med. 2013;158(12):869-876. PMID: 23778904 http://annals.org/article.aspx?articleid=1696644