drug interaction(s) of statins with fibrates

Drug interactions: - clinical benefit of statin-fibrate combinations is unclear - no evidence of additional cardiovascular risk reduction over statin alone - risk of rhabdomyolysis or severe myalgia is significantly increased with combination therapy - risk appears to be dose-dependent

Properties

DRUGS: HMG CoA reductase inhibitor fibrate

References

- Safety of high-dose statin-fibrate combinations National PBM bulletin Nov 10, 2009 Veterans Administration