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drug interaction(s) of tamoxifen with SSRI
Drug interactions:
- CYP2D6-mediated conversion of tamoxifen is inhibited by CYP2D6 inhibitors, including SSRIs paroxetine, fluoxetine, & sertraline
- apparently, citalopram, escitalopram, & fluvoxamine are weaker CYP2D6 inhibitors & their interactions may not be clinically significant
- paroxetine does inhibit benefit of tamoxifen in women with breast cancer
- increased mortality from breast cancer in women taking both tamoxifen & paroxetine relative to tamoxifen alone [2]
- fluoxetine was not found to be associated with an increase in mortality, possibly because the number of women taking both fluoxetine & tamoxifen was low [2]
Properties
DRUGS: tamoxifen
serotonin reuptake inhibitor
References
- Prescriber's Letter 16(7): 2009
COMMENTARY: Tamoxifen and SSRIs: Is There An Interaction?
COMMENTARY: How to Switch Antidepressants
CHART: Cytochrome P450 Drug Interactions
Detail-Document#: 250702
(subscription needed) http://www.prescribersletter.com
- Kelly CM et al
Selective serotonin reuptake inhibitors and breast cancer
mortality in women receiving tamoxifen: a population based
cohort study
BMJ 2010;340:c693
PMID: 20142325
http://www.bmj.com/cgi/content/full/340/feb08_1/c693