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drug interaction(s) of antibiotics with warfarin
Drug interactions:
1) warfarin effect can be INCREASED with:
a) metronidazole
b) macrolides
c) quinolones
d) sulfonamides
e) azoles (fluconazole, ketoconazole, itraconazole..)
2) warfarin effect can be DECREASED if taken with:
a) dicloxacillin [1,2]
b) nafcillin
c) rifampin (may take weeks)
d) griseofulvin (may take weeks)
Properties
DRUGS: antibiotic
warfarin
References
- Prescriber's Letter 16(2): 2008
Antibiotic/Antifungal Drug Interactions and Warfarin
Detail-Document#: 250208
(subscription needed) http://www.prescribersletter.com
- Pottegard A, Henriksen DP, Madsen KG et al
Change in International Normalized Ratio Among Patients Treated
With Dicloxacillin and Vitamin K Antagonists.
JAMA. 2015;314(3):296-297.
PMID: 26197191
http://jama.jamanetwork.com/article.aspx?articleid=2397825