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drug interaction(s) of methotrexate with proton pump inhibitors

Drug interactions: - proton pump inhibitors may increase methotrexate levels by inhibiting its renal clearance [1] - risk is with high-dose methotrexate infusions - problems might also occur with lower doses used for treatment of rheumatoid arthritis [1]

Properties

DRUGS: methotrexate proton pump inhibitor

References

  1. Prescriber's Letter 19(12): 2012 Proton Pump Inhibitor-Methotrexate Interaction Detail-Document#: 281212 (subscription needed) http://www.prescribersletter.com