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drug interaction(s) of antiplatelet agents with proton pump inhibitors

Drug interactions: - proton pump inhibitors may diminish the risk of upper GI bleeding in patients on aspirin, other NSAIDs, clopidogrel or other antiplatelet agents

Properties

DRUGS: antiplatelet agent proton pump inhibitor

References

  1. Prescriber's Letter 15(21): 2008 Reducing the Risk for GI Bleeding with Antiplatelet Drugs Detail-Document#: 241205 (subscription needed) http://www.prescribersletter.com
  2. Hsu P-I et al. Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis. Gastroenterology 2011 Mar; 140:791. PMID: 21144850