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drug interaction(s) of theophylline with fluoroquinolone
Drug interactions:
- coadministration of theophylline with fluoroquinolone (CYP1A2 inhibitors), increases serum concentration of theophylline & potentiates its toxicity
- risk is ~2 fold
Management:
- select antibiotics other than fluoroquinolone for patients on theophylline
Properties
DRUGS: theophylline
fluoroquinolone
References
- Antoniou T, Gomes T, Mamdani MM, Juurlink DN.
Ciprofloxacin-induced theophylline toxicity: a population-based study.
Eur J Clin Pharmacol. 2011 May;67(5):521-6. Epub 2011 Jan 14.
PMID: 21234553