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drug interaction(s) of gliptins with sulfonylureas
Drug interactions:
- combination of gliptin with sulfonylurea
- increases risk for hypoglycemia [1]
- absolute risk 12% vs 7% for sulfonylurea alone [1]
- decreases risk for hypoglycemia (RR = 0.86) [2]
Properties
DRUGS: gliptin
sulfonylurea
References
- Salvo F et al
Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas
and risk of hypoglycaemia: systematic review and meta-analysis.
BMJ 2016;353:i2231
PMID: 27142267 Free full text
http://www.bmj.com/content/353/bmj.i2231
- Hippisley-Cox J, Coupland C
Diabetes treatments and risk of amputation, blindness, severe
kidney failure, hyperglycaemia, and hypoglycaemia: open cohort
study in primary care.
BMJ 2016;352:i1450
PMID: 27029547
http://www.bmj.com/content/352/bmj.i1450
- Montori VM
Selecting the right drug treatment for adults with type 2
diabetes.
BMJ 2016;352:i1663
PMID: 27029501
http://www.bmj.com/content/352/bmj.i1663