Contents

Search

drug interaction(s) of NSAIDs with SSRIs

Drug interactions: - risk of GI bleed, conflicting data a) SSRI used concurrently with NSAIDs increases risk of GI-bleeding 12-fold [1] b) combining an NSAID with an SSRI did not further elevate the risk of GI bleeding [2] c) combination of NSAID with SSRI increases risk of upper GI bleed [3]

Properties

DRUGS: non-steroidal anti-inflammatory agent serotonin reuptake inhibitor

References

  1. Prescriber's Letter 12(7): 2005 Selective Serotonin Reuptake Inhibitors (SSRIs) and Antiplatelet Activity Detail-Document#: 210715 (subscription needed) http://www.prescribersletter.com
  2. Targownik LE et al Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding. Am J Gastroenterol 2009 Jun; 104:1475. PMID: 19491861
  3. Masclee GMC et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology 2014 Oct; 147:784 PMID: 24937265 - Laine L. NSAID-associated gastrointestinal bleeding: Assessing the role of concomitant medications. Gastroenterology 2014 Oct; 147:730. PMID: 25167988