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drug interaction(s) of NSAIDs with antidepressants
Drug interactions:
- increased risk of intracranial hemorrhage (NNH=244)
- no differences among the various antidepressant classes [1]
- relative risk > for men than women
- RR = 2.6 (men) vs 1.2 (women)
Properties
DRUGS: non-steroidal anti-inflammatory agent
antidepressant
References
- Shin JY, Park MJ, Lee SH et al
Risk of intracranial haemorrhage in antidepressant users with
concurrent use of non-steroidal anti-inflammatory drugs:
nationwide propensity score matched study.
BMJ 2015;351:h3517
PMID: 26173947
http://www.bmj.com/content/351/bmj.h3517
- Mercer SW et al
Risk of intracranial haemorrhage linked to co-treatment with
antidepressants and NSAIDs.
BMJ 2015;351:h3745
PMID: 26173949
http://www.bmj.com/content/351/bmj.h3745