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drug interaction(s) of warfarin with NSAIDs

Drug interactions: - coadministration of warfarin with NSAIDS may increase risk of hematuria, hemotoma & other hemorrhage, especially in elderly on complex drug regimens - NSAIDs in combination with warfarin did not increase risk of bleeding [3]

Properties

DRUGS: warfarin non-steroidal anti-inflammatory agent

References

  1. Gabb GM. Fatal outcome of interaction between warfarin and a non-steroidal anti-inflammatory drug. Med J Aust. 1996 Jun 3;164(11):700-1. PMID: 8657040.
  2. Schulman S, Henriksson K. Interaction of ibuprofen and warfarin on primary haemostasis. Br J Rheumatol. 1989 Feb;28(1):46-9. PMID: 2783873
  3. Dalgaard F, Mulder H, Wojdyla DM et al. Patients with atrial fibrillation taking nonsteroidal anti- inflammatory drugs and oral anticoagulants in the ARISTOTLE trial. Circulation 2019 Nov 21 PMID: 31747786 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041296