Search
drug interaction(s) of spironolactone with trimethoprim
Drug interactions:
- spironolactone in combination with trimethoprim (including trimethoprim/sulfamethoxazole) potentiates hyperkalemia in the elderly
- combination increases risk of sudden death in elderly [2]
Properties
DRUGS: spironolactone
trimethoprim
References
- Antoniou T et al.
Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly
patients receiving spironolactone: Nested case-control study.
BMJ 2011 Sep 12; 343:d5228
PMID: 21911446
- Antoniou T et al.
Trimethoprim-sulfamethoxazole and risk of sudden death among
patients taking spironolactone.
CMAJ 2015 Mar 3; 187:E138
PMID: 25646289
http://www.cmaj.ca/content/187/4/E138