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drug interaction(s) of antidepressant with opiates
Drug interactions:
- combination of CYP2D6-metabolized opiates* with CYP2D6-inhibiting antidepressants* is associated with worsening pain increased risk of opioid-related adverse events among older nursing home residents [1]
* - CYP2D6-metabolized opiates
- hydrocodone, codeine, tramadol, oxycodone
* - CYP2D6-inhibiting antidepressants
- fluoxetine, paroxetine, duloxetine, doxepin, bupropion
Properties
DRUGS: antidepressant
opioid agonist
References
- Wei YJJ et al
Clinical and Adverse Outcomes Associated With Concomitant Use of CYP2D6-Metabolized
Opioids With Antidepressants in Older Nursing Home Residents.
A Target Trial Emulation Study.
Ann Intern Med. 2024. July 23
PMID: 39038293
https://www.acpjournals.org/doi/10.7326/M23-3109