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drug interaction(s) of MAO inhibitor with caffeine

Drug interactions: - high caffeine intake combined with MAO inhibitor therapy can lead to severe hypertension [1]* * case report of patient drinking 10-12 cups of coffee/day while taking tranylcypromine [1] with BP of 220/120 mm Hg; BP returned to normal when he switched to decaf. Management: - limit caffeine intake to <= 200 mg/day for patients taking MAO inihibitors

Properties

DRUGS: monoamine oxidase inhibitor caffeine

References

  1. van der Hoeven N et al Severe Hypertension Related to Caffeinated Coffee and Tranylcypromine: A Case Report. Ann Intern Med. 2014;160(9):657-658. PMID: 24798537 http://annals.org/article.aspx?articleid=1867070