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drug interaction(s) of NSAIDs with aldosterone antagonis

Drug interactions: - combination of NSAID with aldosterone antagonst increases risk of upper GI bleed (RR= 11.0)

Properties

DRUGS: non-steroidal anti-inflammatory agent aldosterone receptor antagonist

References

  1. Masclee GMC et al. Risk of upper gastrointestinal bleeding from different drug combinations. Gastroenterology 2014 Oct; 147:784 PMID: 24937265 - Laine L. NSAID-associated gastrointestinal bleeding: Assessing the role of concomitant medications. Gastroenterology 2014 Oct; 147:730. PMID: 25167988