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drug interaction(s) of simvastatin, verapamil & grapefruit

Drug interactions: - both verapamil & grapefruit inhibit CYP3A4 which metabolizes simvastation - simvastatin dose with verapamil (without grapefruit) should not exceed 10 mg/day - rhabdomyolysis occurs with simvastatin toxicity

Properties

DRUGS: simvastatin verapamil grapefruit

References

  1. Paauw DS Dangerous and Deadly Drug Combinations Medscape. June 30, 2016 http://www.medscape.com/features/slideshow/dangerous-drug-combinations