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drug interaction(s) of NSAIDs with ACE inhibitors

Drug interactions: 1) ACE inhibitors increase prostaglandins that cause vasodilation; NSAIDs inhibit cyclooxygenase, thus formation of prostaglandins 2) prostaglandins act on afferent glomerular arterioles, ACE inhibitors act on efferent glomerular arterioles 3) increased risk of hyperkalemia 4) NSAIDs may interfere with antihypertensive effects of ACE inhibitors 5) when combined with diuretic, further increases risk of acute renal failure [2] Management: - 81 mg of aspirin recommended for use in combination with ACE inhibitor, when both are indicated.

Properties

DRUGS: non-steroidal anti-inflammatory agent ACE inhibitor

References

  1. Prescriber's Letter 10(9):51 2003
  2. Prescriber's Letter 18(12): 2011 NSAIDs and Hypertension Detail-Document#: 271224