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drug interaction(s) of NSAIDs & antihypertensives

Drug interactions: - NSAIDs can reduce the effectiveness of antihypertensive agents - NSAIDS increase arterial smooth-muscle tone via prostaglandin inhibition & produce a dose-related effect on natriuresis, resulting in fluid retention - greatest effect with indomethacin, piroxicam, & naproxen - intermediate effect with ibuprofen, rofecoxib, & celecoxib - aspirin does not significantly increase blood pressure

Properties

DRUGS: non-steroidal anti-inflammatory agent antihypertensive agent

References

  1. Paauw DS Dangerous and Deadly Drug Combinations Medscape. June 30, 2016 http://www.medscape.com/features/slideshow/dangerous-drug-combinations