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drug adverse effects of calcineurin inhibitors

Adverse effects: - hypertension (treated with thiazide diuretics) - oral calcineurin inhibitors cyclosporine & tacrolimus are associated with excess risk for non-melamoma skin cancers & lymphomas - topical calcineurin inhibitors tacrolimus & pimecrolimus are not [3] - topical calcineurin inhibitors are associated with increased risk of lymphomas (RR=1.9) [4]

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DRUGS: calcineurin inhibitor FORM: drug adverse effects calcineurin inhibitor

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 18 American College of Physicians, Philadelphia 2018
  2. Moes AD, Hesselink DA, Zietse R et al Calcineurin inhibitors and hypertension: a role for pharmacogenetics? Pharmacogenomics. 2014 Jun;15(9):1243-51. Review. PMID: 25141899
  3. Asgari MM et al. Association between topical calcineurin inhibitor use and keratinocyte carcinoma risk among adults with atopic dermatitis. JAMA Dermatol 2020 Aug 12; [e-pub] PMID: 32785626 https://jamanetwork.com/journals/jamadermatology/fullarticle/2768937
  4. Lam M, Zhu JW, Tadrous M et al Association Between Topical Calcineurin Inhibitor Use and Risk of Cancer, Including Lymphoma, Keratinocyte Carcinoma, and Melanoma. A Systematic Review and Meta-analysis. JAMA Dermatol. Published online March 31, 2021 PMID: 33787818 https://jamanetwork.com/journals/jamadermatology/fullarticle/2778024