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drug adverse effects of P2Y12 receptor inhibitor(s)
Adverse effects:
- prasugrel & ticagrelor more potent antiplatelet agents than clopidogrel & superior in preventing ischemic events, at the cost of increased risk of bleeding [1]
- genetic testing may provide some information on risk of bleeding [1]
Properties
DRUGS: P2Y12-receptor inhibitor
FORM: drug adverse effects p2y12 receptor inhibitor
References
- Susman E.
Genetic Testing Aids in Anticoagulant Selection in ACS.
Personalized approach tied to clinically meaningful reduction
in ischemic and bleeding events.
MedPage Today. March 12, 2018
https://www.medpagetoday.com/meetingcoverage/acc/71722
- Ardissino D, et al
A prospective, randomised, multicentre study of a
pharmacogenomic approach to the selection of antiplatelet
therapy in acute coronary syndromes.
American College of Cardiology (ACC) 2018;
Abstract 18-LB-18910-ACC.
- Notarangelo FM, Maglietta G, Bevilacqua P, et al
Pharmacogenomic approach to selecting antiplatelet therapy in
acute coronary syndromes: PHARMCLO trial.
J Am Coll Cardiol. March 2018
PMID: 29540324
http://www.onlinejacc.org/content/early/2018/02/23/j.jacc.2018.02.029