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drug adverse effects of macrolide(s)
Adverse effects:
- use during pregnancy not associated with increased risk of birth defects [1]
- use during pregnancy is associated with increased risk of birth defects [2]
- dose-dependent association with tinnitus [3]
Properties
DRUGS: macrolide
FORM: drug adverse effects macrolide
References
- Berard A et al
Use of macrolides during pregnancy and the risk of birth
defects: a population-based study.
Pharmacoepidemiology and Drug Safety. Oct 29, 2015
PMID: 26513406
http://onlinelibrary.wiley.com/doi/10.1002/pds.3900/abstract;jsessionid=D48B754D181DE5E6CC5507D7E5D0E6FC.f03t01
- Fan H, Gilbert R, O'Callaghan F, Li L.
Associations between macrolide antibiotics prescribing during
pregnancy and adverse child outcomes in the UK: population based
cohort study.
BMJ 2020;368:m331
PMID: 32075790 Free Article
https://www.bmj.com/content/368/bmj.m331
- Vanoverschelde A, Oosterloo BC, Ly NF et al.
Macrolide-associated ototoxicity: A cross-sectional and longitudinal study
to assess the association of macrolide use with tinnitus and hearing loss.
J Antimicrob Chemother 2021 Jul 27; [e-pub].
PMID: 34312676
https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkab232/6328751