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drug adverse effects of cephalosporins
Adverse effects:
1) Stevens-Johnson syndrome
2) erythema multiforme
3) toxic epidermal necrolysis
4) renal dysfunction
5) toxic nephropathy
6) aplastic anemia
7) hemolytic anemia
8) hemorrhage
9) cholestasis
10) pancytopenia
11) seizures [2]
12) cephalosporin allergy uncommon [3]
- patients with allergy to one cephalosporin can often tolerate others [4]
13) acute generalized exanthematous pustulosis [5]
Properties
DRUGS: cephalosporin
FORM: drug adverse effects cephalosporin
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Medications Can Cause Seizures
Prescriber's Letter 10(3):16 2003
Detail-Document#: 190320
(subscription needed) http://www.prescribersletter.com
- Macy E, Contreras R.
Adverse reactions associated with oral and parenteral use
of cephalosporins: A retrospective population-based analysis.
J Allergy Clin Immunol 2015 Mar; 135:745
PMID: 25262461
http://www.jacionline.org/article/S0091-6749%2814%2901193-2/abstract
- Romano A et al.
IgE-mediated hypersensitivity to cephalosporins: Cross-reactivity
and tolerability of alternative cephalosporins.
J Allergy Clin Immunol 2015 Sep; 136:685
PMID: 25930196
http://www.jacionline.org/article/S0091-6749%2815%2900410-8/abstract
- Aday AW et al
CLINICAL PROBLEM-SOLVING. Prevention as Precipitant.
N Engl J Med 2016; 375:471-475. August 4, 2016
PMID: 27518666
http://www.nejm.org/doi/full/10.1056/NEJMcps1301580