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drug adverse effects of sulfonamides
Adverse effects:
- hypersensitivity*
- use during pregnancy associated with birth defects, including:
a) anencephaly
b) left-sided heart defects
- precipitation of acute intermittent porphyria [13]
* PEN-FAST (SULF-FAST) criteria for predicting sulfonamide hypersensitivity
- allergic event occurred anaphylaxis/angioedema or severe cutaneous adverse reaction (2 points)
- treatment was required for allergic event (1 point)
* a PEN-FAST (SULF-FAST) of <3 associated with <5% risk of hypersensitivity reaction
- a score >= 3 associated with >20% risk of hypersensitivity reaction [2]
Properties
DRUGS: sulfonamide
FORM: drug adverse effects sulfonamide
References
- Crider KS et al
Antibacterial Medication Use During Pregnancy and Risk of
Birth Defects. National Birth Defects Prevention Study
Arch Pediatr Adolesc Med. 2009;163(11):978-985
PMID: 19884587
http://archpedi.ama-assn.org/cgi/content/short/163/11/978
- Waldron JL et al.
Development and validation of a sulfa antibiotic allergy clinical decision rule.
JAMA Netw Open 2023 Jun 5; 6:e2316776.
PMID: 37273210 PMCID: PMC10242418 Free PMC article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805577
- NEJM Knowledge+