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drug adverse effects of aminoglycosides
Adverse effects:
1) ototoxicity
a) tinnitus
b) vestibular toxicity may occur up to 2-3 months after stopping drug
2) nephrotoxicity
a) occurs after 5-7 days of therapy & correlates with the cumulative dose
b) often non-oliguric acute tubular necrosis
c) once a day dosing may reduce nephrotoxicity
d) even low-dose aminoglycosides may be nephrotoxic [1]
Properties
DRUGS: aminoglycoside antibiotic
FORM: drug adverse effects aminoglycoside antibiotic
References
- Cosgrove SE et al.
Initial low-dose gentamicin for Staphylococcus aureus
bacteremia and endocarditis is nephrotoxic.
Clin Infect Dis 2009 Mar 15; 48:713.
PMID: 19207079
- Bayer AS and Murray BE
Initial low-dose aminoglycosides in Staphylococcus aureus
bacteremia: Good science, urban legend, or just plain toxic?
Clin Infect Dis 2009 Mar 15; 48:722.
PMID: 19207080