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drug adverse effects of long-acting beta-adrenergic receptor agonists

Adverse effects: - when taken without an inhaled corticosteroid, may increase risk for death [2,3,4]* - Advair Diskus, Foradil Aerolizer, & Serevent Diskus may increase the chance of severe asthma episodes, & death when those episodes occur - increased cardiovascular risk in the elderly - highest risk 2-3 weeks after starting treatment [5] * risk for asthmatics > risk for patients with COPD

Properties

DRUGS: long-acting beta adrenergic receptor agonist FORM: drug adverse effects long acting beta adrenergic receptor agonist

References

  1. FDA Medwatch http://www.fda.gov/medwatch/safety/2005/safety05.htm#LABA
  2. FDA advisory panel meeting Joint Meeting of the Pulmonary-Allergy Drugs Advisory Committee, Drug Safety & Risk Management Advisory Committee, and the Pediatric Advisory Committee December 10 & 11, 2008 http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4398b1-00-index.htm - Bateman E et al Effects of adding salmeterol to inhaled corticosteroids on serious asthma-related events. Ann Intern Med. 2008 Jul 1;149(1):33-42. Epub 2008 Jun 3. PMID: 18523132 http://www.annals.org/cgi/content/full/0000605-200807010-00229v1 - Weiss KB. Drug safety and salmeterol: The controversy continues. Ann Intern Med. 2008 Jul 1;149(1):56-7. Epub 2008 Jun 3. PMID: 18523131 http://www.annals.org/cgi/content/full/0000605-200807010-00230v1
  3. Prescriber's Letter 16(1): 2009 Safety of Long-Acting Beta-Agonists in Asthma Detail-Document#: 250102 (subscription needed) http://www.prescribersletter.com
  4. Prescriber's Letter 17(4): 2010 New Safety Requirements for Long-Acting Beta-Agonists (LABAs) COMMENTARY: New Safety Requirements for Long-Acting Beta-Agonists (LABAs) COMMENTARY: Childhood Asthma Treatment: The BADGER Study Detail-Document#: 260401 (subscription needed) http://www.prescribersletter.com
  5. Gershon A et al Cardiovascular Safety of Inhaled Long-Acting Bronchodilators in Individuals With Chronic Obstructive Pulmonary Disease. JAMA Intern Med. 2013;():1-9. PMID: 23689820 http://archinte.jamanetwork.com/article.aspx?articleid=1689974