drug adverse effects of alkylating agents

Adverse effects: 1) increased incidence of acute myelocytic leukemia (AML) a) often preceded by myelodysplastic syndrome b) peak incidence 4-6 years after alkylating agent therapy 2) non-random cytogenetic abnormalities a) chromosome 7 deletions b) trisomy 8

Properties

DRUGS: alkylating agent FORM: drug adverse effects alkylating agent

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998