Contents

Search

drug adverse effects of calcium channel blockers

Adverse effects: 1) pedal edema 2) bradycardia 3) tachycardia 4) orthostatic hypotension 5) constipation 6) GERD via lowering of esophageal sphincter tone 7) urinary retention via relaxation of bladder smooth muscle 8) eczema, pruritus (especially chronic therapy in elderly) [2,3,9,10] - generally occurs about 3 months after starting drug [3] - histopathology may be spongiform [9] 9) photosensitivity [3] 10) erythema multiforme, exfoliative dermatitis [3] (rare) 11) long-term use of calcium channel blocker associated with > 2-fold increased risk of breast cancer in postmenopausal women [7] - no association with increased risk for breast cancer [8] 12) in older adults > 66 years of age, prescription of calcium-channel blocker associated with increase likelihood of later prescription of loop diuretic [11] Overdose: - tetrad of hypotension, bradycardia, hyperglycemia, metabolic acidosis - also see calcium channel blocker

Properties

DRUGS: calcium channel blocker FORM: drug adverse effects calcium channel blocker

References

  1. Daubert GP, Emergency Medicine, University of California, Davis
  2. Joly P et al, Chronic eczematous eruptions of the elderly are associated with chronic exposure to calcium channel blockers: Results from a cases-control study. J Invest Dermatol 2007, 127:2766 PMID: 17713574 - Stern RS Chronic medication use and inflammatory skin diseases: The power and limitations of the case-control study. J Invest Dermatol 2007, 127:2709 PMID: 18007690
  3. Prescriber's Letter 15(4): 2008 Calcium Channel Blockers (CCBs) and Eczema Detail-Document#: 240402 (subscription needed) http://www.prescribersletter.com
  4. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
  5. The Washington Manual of Medical Therapeutics, 33rd edition Foster C et al (eds) Lippincott, Williams & Wilkins, Philadelphia, 2010, pg 971
  6. Summers EM et al. Chronic eczematous eruptions in the aging: Further support of an association with exposure to calcium channel blockers. JAMA Dermatol 2013 May 1 PMID: 23636109 http://archderm.jamanetwork.com/article.aspx?articleid=1684846
  7. Li CI, Daling JR, Tang MT et al Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years. JAMA Intern Med. August 5, 2013 PMID: 23921840 http://archinte.jamanetwork.com/article.aspx?articleid=1723871 - Coogan PF Calcium-Channel Blockers and Breast Cancer.A Hypothesis Revived. JAMA Intern Med. August 5, 2013 PMID: 23921818 http://archinte.jamanetwork.com/article.aspx?articleid=1723870
  8. InterMountain Health Care. Study deputes previous claims that calcium channel blocker meds cause breast cancer. http://intermountainhealthcare.org/hospitals/imed/services/heart-institute/about/Pages/news.aspx?NewsID=1867
  9. Summers EM, Bingham CS, Dahle KW, et al. Chronic eczematous eruptions in the aging: further support for an association with exposure to calcium channel blockers. JAMA Dermatol. 2013;149(7):814-818. PMID: 23636109
  10. Orme S, da Costa D. Generalised pruritus associated with amlodipine. BMJ. 1997;315(7106):463. PMID: 9284667
  11. Savage RD, Visentin JD, Bronskill SE et al. Evaluation of a common prescribing cascade of calcium channel blockers and diuretics in older adults with hypertension. JAMA Intern Med 2020 Feb 24; PMID: 32091538 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2761272
  12. DeWitt CR, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker toxicity. Toxicol Rev 2004; 23:223 PMID: 15898828