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drug adverse effects of estrogens
Adverse effects:
1) increased risk of thromboembolic events*
2) increased risk of endometrial carcinoma if administered without progestin
3) increased growth of estrogen-dependent tumors
a) breast cancer
b) ovarian cancer [1]
4) may increase risk of stroke
5) increases risk of cholelithiasis & cholecystitis [3]
* mediated through 1st pass metabolism in liver; transdermal estrogen may not increase risk [4]
Properties
DRUGS: estrogen
FORM: drug adverse effects estrogen
References
- Journal Watch 21(9):72, 2001
Rodriguez et al, JAMA 285:1460, 2001
- Geriatrics Review Syllabus, American Geriatrics Society,
5th edition, 2002-2004
- Journal Watch 25(4):29, 2005
Cirillo DJ, Wallace RB, Rodabough RJ, Greenland P, LaCroix AZ,
Limacher MC, Larson JC.
Effect of estrogen therapy on gallbladder disease.
JAMA. 2005 Jan 19;293(3):330-9.
PMID: 15657326
- Canonico M et al.
Postmenopausal hormone therapy and risk of idiopathic venous
thromboembolism: Results from the E3N cohort study.
Arterioscler Thromb Vasc Biol 2010 Feb; 30:340.
PMID: 19834106
- Cushman M.
Patch instead of pill: A safer menopausal estrogen?
Arterioscler Thromb Vasc Biol 2010 Feb; 30:136
PMID: 20089948