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drug adverse effects of dopaminergic receptor agonists

Adverse effects: 1) anorexia 2) nausea/vomiting 3) dizziness 4) dyskinesia a) usually choreiform movements b) effect is dose dependent c) generally occurs after prolonged therapy 5) psychosis a) visual hallucinations b) vivid nightmares c) paranoid delusions 6) impulse control disorders [6,7] 7) compulsive behavior - punding [5] - gambling, shopping, hypersexuality [3] 8) dementia 9) depression 10) excessive daytime sleepiness & sleep attacks [2] 11) sedation [5] 12) peripheral edema 13) adverse effects are dose-dependent & minimized by slow titration 14) abrupt withdrawal of dopamine agonists has been associated with a syndrome resembling neuroleptic malignant syndrome or akinetic crises - taper to discontinue [4]

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DRUGS: dopaminergic receptor agonist FORM: drug adverse effects dopaminergic receptor agonist

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1051
  2. Prescriber's Letter 9(3):17 2002
  3. Bronstein J, In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
  4. FDA MedWatch http://www.fda.gov/medwatch/safety/2008/safety08.htm#neupro
  5. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  6. Moore TJ et al Reports of Pathological Gambling, Hypersexuality, and Compulsive Shopping Associated With Dopamine Receptor Agonist Drugs. JAMA Intern Med. Published online October 20, 2014. PMID: 25329919 http://archinte.jamanetwork.com/article.aspx?articleid=1916909 - Gagne JJ Finding Meaningful Patterns in Adverse Drug Event Reports. JAMA Intern Med. Published online October 20, 2014 PMID: 25329621 http://archinte.jamanetwork.com/article.aspx?articleid=1916906 - Weiss HD, Pontone GM Dopamine Receptor Agonist Drugs and Impulse Control Disorders. JAMA Intern Med. Published online October 20, 2014 PMID: 25329734 http://archinte.jamanetwork.com/article.aspx?articleid=1916907
  7. Corvol JC, Artaud F, Cormier-Dequaire F et al. Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology. 2018 Jul 17;91(3):e189-e201. PMID: 29925549 http://n.neurology.org/content/91/3/e189Corvol JC, Artaud F, Cormier-Dequaire F et al. Longitudinal analysis of impulse control disorders in Parkinson disease. Neurology. 2018 Jul 17;91(3):e189-e201. PMID: 29925549 http://n.neurology.org/content/91/3/e189