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drugs that may affect liver function tests (LFTs)
Etiology:
1) drugs causing BOTH hepatocellular injury & cholestasis [1]
- acetohexamide
- allopurinol
- aminosalicylic acid
- amodiaquine
- Amphotericin B
- anabolic agents
- androgens
- chlorpropamide
- cyclophosphamide
- desipramine
- erythromycin
- glycopyrrolate
- haloperidol
- halothane
- hydrazine
- imipramine
- indomethacin
- isoniazid
- lincomycin
- MAO inhibitors
- mercaptopurine
- metaxalone
- methoxysalen
- methoxyflurane
- methyldopa
- methylthiouracil
- nicotinic acid
- nitrofurantoin
- novobiocin
- oleandomycin
- oxazepam
- oxyphenbutazone
- paraldehyde
- paramethadione
- phenacemide
- phenacetin
- phenothiazines
- phenylbutazone
- progestins
- propylthiouracil
- quinacrine (mepacrine)
- sulfonamides
- tetracyclines
- thiosemicarbazones
- thiothixene
- tolazamide
- tolbutamide
- trimethadione
- uracil mustard
2) drugs causing cholestasis [2]:
- aminosalicylic acid
- amitriptyline
- anabolic steroids
- androgens
- azathioprine
- benzodiazepines
- carbamazepine
- carbarsone
- chlorthiazide
- chlorpropamide
- clavulanic acid
- dapsone
- erythromycin
- estrogens
- ethionamide
- glyburide (glibenclamide)
- gold salts
- imipramine
- mercaptopurine
- methimazole
- mitoxnatrone
- nicotinic acid
- nitrofurantoin
- oral contraceptives
- penicillamine
- penicillins
- phenothiazines
- phenylbutazone
- progestins
- propoxyphene
- sulfonamides
- sulfones
- sulindac
- tamoxifen
- tolbutamide
3) drugs causing hepatocellular injury [2]:
- acetaminophen
- allopurinol
- aminosalicylic acid
- amiodarone
- amitriptyline
- androgens
- asparaginase
- aspirin
- azathioprine
- carbamazepine
- chenodiol
- chlorambucil
- chloramphenicol
- chlorpropamide
- cimetidine
- cyclosporine
- danazol
- dantrolene
- dapsone
- diclofenac
- dicoumarol (rare)
- disulfiram
- estrogens
- ethanol
- ethionamide
- etretinate
- fluconazole
- halothane
- ibuprofen
- imipramine
- indomethacin
- iron salts (overdose)
- isoniazid
- ketoconazole
- MAO inhibitors
- mercaptopurine
- methotrexate
- methoxyflurane
- methyldopa
- naproxen
- nicotinic acid
- nitrofurantoin
- oral contraceptives
- papaverine
- paramethadione
- perhexiline
- phenazopyridine
- phenindione
- phenobarbital
- phenylbutazone
- phenytoin
- plicamycin (mithramycin)
- probenecid
- procainamide
- propylthiouracil
- pyrazinamide
- quinidine
- rifampin
- salicylates
- sulfasalazine
- sulfonamides
- tamoxifen
- tetracyclines
- trimethadione
- valproic acid
- vitamin A
- warfarin (rare)
Laboratory:
1) increased urine bilirubin
2) increased serum alkaline phosphatase (ALP)
3) increased serum bilirubin
4) increased serum alanine aminotransferase (ALT)
5) increased serum aspartate aminotransferase (AST)
6) decreased serum glucose
Related
elevated serum transaminases; transaminitis; abnormal liver function tests
References
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996, pg 9
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995