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drugs associated with weight gain

Etiology: 1) phenothiazines (descending order of association) - chlorpromazine - thioridazine - trifluoperazine - mesoridazine - promazine - mepazine - perphenazine - prochlorperazine - haloperidol - loxapine 2) atypical antipsychotics [2] - clozapine (Clozaril) - olanzapine (Zyprexa) - quetiapine (Seroquel) - aripiprazole (Abilify) - risperidone (Risperdal) - ziprasidone (Geodon) 3) antidepressants (descending order of association) a) amitriptyline b) imipramine, doxepin, phenelzine c) amoxapine, desipramine, trazodone, tranylcypromine (by group) d) Monoamine Oxidase Inhibitors - Isocarboxazid (Marplan) (controversial) - Phenelzine (Nardil) {most likely in this group} - Tranylcypromine (Parnate) (controversial) e) Atypical antidepressants - Mirtazapine (Remeron) f) Selective Serotonin-Reuptake Inhibitors - Citalopram (Celexa) - escitalopram - Fluoxetine (Prozac) - Paroxetine (Paxil) g) Tricyclic Antidepressants - Amitriptyline (Elavil) - Clomipramine (Anafranil) - Desipramine (Norpramin) {least likely in this group} - Doxepin (Sinequan) - Imipramine (Tofranil) - Maprotiline (Ludiomil) 4) mood stabilizer - pharmceutical lithium 5) anti-epileptics (anticonvulsants) - valproate - carbamazepine (Tegretol) - gabapentin (Neurontin) - pregabalin (Lyrica) 6) steroids - glucocorticoids - prednisone - megestrol - Medroxyprogesterone injection (Depo-Provera) - Hormones-Oral contraceptives & menopausal hormone therapy do not cause weight gain) 7) antihypertensives a) Alpha-Blockers - Prazosin (Minipress) - Terazosin (Hytrin) b) Beta-blockers - Atenolol (Tenormin) - Propranolol (Inderal) - Metoprolol (Loressor, Tropol XL) c) Centrally Acting Agents - Clonidine (Catapres) - Guanabenz (Wytensin) - Guanethidine (Ismelin) - Methyldopa (Aldomet) d) Vasodilator - Minoxidil (Loniten) 7) Antihistamines (H1-Blockers) 1) Diphenhydramine (Benadryl) 2) Fexofenadine (Allegra) 3) Hydroxyzine (Vistaril) 4) cyproheptadine (Periactin) 9) Hypoglycemics a) Insulin b) Meglitinides c) Nateglinide (Starlix) d) Repaglinide (Prandin) e) Sulfonylureas - Chlorpropamide (Diabinese) - Glimepiride (Amaryl) - Glipizide (Glucotrol) - Glyburide (Glynase) {appears to cause most weight gain} - Tolbutamide (Orinase) f) Thiazolidinediones - Pioglitazone (Actos) - Rosiglitazone (Avandia)

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weight gain

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drug adverse effect(s) of

References

  1. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 457
  2. Prescriber's Letter 9(3):17 2002
  3. Prescriber's Letter 14(3): 2007 Drugs Associated with Weight Gain Detail-Document#: 230312 (subscription needed) http://www.prescribersletter.com
  4. Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2012.