drebrin-like protein (SH3 domain-containing protein 7, drebrin-F, cervical SH3P7, HPK1-interacting protein of 55 kD, HIP-55, cervical mucin-associated protein, DBNL, CMAP, SH3P7, PP5423)

Function: 1) actin-binding adapter protein 2) common effector of antigen receptor-signaling pathways in leukocytes (putative) 3) association with dynamin suggests that it may connect the actin cytoskeleton to endocytic function 4) component of the 'immunological synapse' that regulates T-cell activation by bridging TCRs & the actin cytoskeleton to gene activation & endocytic processes 5) binds to F-actin but is not involved in actin polymerization, capping or bundling 6) does not bind G-actin 7) interacts with SHANK2 & SHANK3 via SH3 domain 8) interacts with FGD1, dynamin, MAP4K1 9) degraded by caspases during apoptosis Structure: - contains 1 ADF-H domain - contains 1 SH3 domain Compartment: - cytoplasm; cytoskeleton - cortical cytoskeleton - associates with lamellipodial actin Alternative splicing: named isoforms=3

General

cytoskeletal protein phosphoprotein

Properties

SIZE: MW = 48 kD entity length = 430 aa COMPARTMENT: cytoplasm MOTIF: ADF-H {4-133} Tyr phosphorylation site {Y162} coiled coil {176-231} Ser phosphorylation site {S232} Ser phosphorylation site {S269} Ser phosphorylation site {S272} Ser phosphorylation site {S283} Tyr phosphorylation site {Y334} Tyr phosphorylation site {Y344} src homology 3 [SH3] domain SITE: 371-430

Database Correlations

UniProt Q9UJU6 PFAM correlations

References

UniProt :accession Q9UJU6