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drebrin; drebrin-1; developmentally-regulated brain protein (DBN1, D0S117E)
Function:
- actin-binding protein highly enriched in dendritic spines
- regulates dendritic spine morphogenesis prior to formation of postsynaptic densities
- drebrin-1 recruits PSD-95 to the post-synaptic density.
- forms clusters in dendritic filopodia
- drebrins might play some role in cell migration, extension of neuronal processes & plasticity of dendrites
- binds F-actin
Structure: contains 1 ADF-H domain
Compartment:
- cytoplasm, highly enriched in dendritic spines
Alternative splicing:
- named isoforms=2; drebrin E (embryonic form) & drebrin A (adult form)
- drebrin A is neuron-specific
Expression:
- brain, neurons
- also found in the heart, placenta, skeletal muscle, kidney & pancreas
Pathology:
- a decrease in drebin 1 has been reported in brains of patients with Alzheimer's disease & Down syndrome.
Related
neuronal PAS domain-containing protein 4 (neuronal PAS4, HLH-PAS transcription factor NXF, NPAS4, NXF)
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: entity length = 649 aa
MW = 71 kD
COMPARTMENT: cytoplasm
CELL-REGION: dendrite
CELL: neuron
WITHIN: neuron
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
ADF-H {3-134}
MOTIF: Ser phosphorylation site {S134}
Ser phosphorylation site {S141}
Ser phosphorylation site {S142}
Thr phosphorylation site {T331}
Thr phosphorylation site {T335}
Ser phosphorylation site {S337}
Ser phosphorylation site {S339}
Ser phosphorylation site {S342}
Thr phosphorylation site {T343}
Ser phosphorylation site {S345}
Thr phosphorylation site {T346}
Ser phosphorylation site {S601}
Tyr phosphorylation site {Y622}
Database Correlations
OMIM 126660
UniProt Q16643
Pfam PF00241
Entrez Gene 1627
Kegg hsa:1627
References
- OMIM :accession 126660
- Takahashi H et al. J Neurosci 2003, 23(16):6586-6595
http://www.jneurosci.org/cgi/content/abstract/23/16/6586?etoc
- Neurosciences Abstract 2003
- Entrez Gene :accession 1627
- UniProt :accession Q16643