protein Dr1; down-regulator of transcription 1; TATA-binding protein-associated phosphoprotein; negative cofactor 2-beta; NC2-beta (DR1)

Function: - association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated & basal transcription of class II genes - this interaction precludes the formation of a transcription- competent complex by inhibiting the association of TFIIA &/or TFIIB with TBP - can bind to DNA on its own - heterodimer with DRAP1 - DR1 exists in solution as a homotetramer that dissociates during interaction with TBP & then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer - interacts with NFIL3 - phosphorylation regulates its interaction with TBP - not phosphorylated when bound to DRAP1 Structure: - belongs to the NC2 beta/DR1 family - contains 1 histone-fold domain Compartment: nucleus

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 176 aa MW = 19 kD COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {100-103} Ser phosphorylation site {S105} glutamine-rich region {121-168} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 601482 UniProt Q01658 Pfam PF00808 Kegg hsa:1810

References

UniProt :accession Q01658