DP2/E2F complex

Function: - probably similar to DP1/E2F complex - the DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase - E2F-1/DP complex appears to mediate both cell proliferation & apoptosis - forms heterodimers with E2F family members - the complex can interact with hypophosphorylated RB1 & related proteins (RBL1 & RBL2) that inhibit the E2F transactivation domain

General

DNA-binding protein transcription factor complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SUBUNITS: transcription factor Dp-2 COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S24} Ser phosphorylation site {S42} nuclear translocation signal {103-118} DNA-binding motif SITE: 129-210 MOTIF: DEF box {176-210} Dimerization {219-292} MOTIF: DCB1 {229-261} DCB2 {274-330} acidic region {432-446} MOTIF: acidic residue (SEVERAL) E2F MOTIF: binding site SITE: N-TERMINAL FOR-BINDING-OF: CDK2/cyclin A complex domain {CENTRAL} MOTIF: DNA-binding motif binding site FOR-BINDING-OF: transcription factor DP-1 phosphorylation site binding site SITE: C-TERMINAL FOR-BINDING-OF: retinoblastoma-associated protein

References

UniProt :accession Q14188

Components

E2F transcription factor Dp-2; E2F dimerization partner 2 (TFDP2, DP2)