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doxylamine/pyridoxine (Diclegis, Bendectin)
Indications:
- nausea/vomiting associated with pregnancy (morning sickness)
- may not be as effective as previously reported [2]
Dosage:
- start 2 tablets at bedtime
- maximum dose 4 tablest/day
- 1 tablet in the morning
- 1 tablet at noon
- 2 tables at bedtime
- tablets must be taken on an empty stomach
Adverse effects:
- drowsiness or sleepiness (may be severe)
Notes:
- Bendectin was voluntarily pulled from the market in 1983 due to concerns about birth defects
- those concerns later proved to be unfounded
General
pharmacologic combination
References
- FDA News Release: April 8, 2013
FDA approves Diclegis for pregnant women experiencing nausea
and vomiting.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm347087.htm
- Persaud N, Meaney C, El-Emam K, Moineddin R, Thorpe K.
Doxylamine-pyridoxine for nausea and vomiting of pregnancy
randomized placebo controlled trial: Prespecified analyses and
reanalysis.
PLOS One. January 17, 2018
PMID: 29342163 Free full text
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189978
Components
doxylamine (UniSom)
pyridoxine (a vitamin B6)