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doxapram (Dopram)
Tradename: Dopram.
Indications:
- drug-induced or post-anesthesia respiratory depression
- apnea
Dosage:
1) initial dose: 0.5-1 mg/kg IV
2) repeat every 5min up to max of 2 mg/kg
3) IV infusion:
a) 5 mg/min until response or adverse reaction
b) decrease to 1-3 mg/min
4) max dose 300 mg
Adverse effects:
1) ectopic heartbeats
2) hypotension
3) angina
4) vasoconstriction
5) tachycardia
6) headache
7) nausea/vomiting
Mechanism of action:
- stimulation of the respiratory centers in the medulla & carotid chemoreceptors
Interactions
drug adverse effects (more general classes)
General
analeptic (CNS stimulant)
Properties
MISC-INFO: elimination route LIVER
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998