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Down syndrome cell adhesion molecule (CHD2, DSCAM)
Function:
1) cell adhesion molecule
2) mediates cation-independent homophilic binding activity
3) nervous system development Isoform Long: cell membrane Isoform Short: secreted
Alternative splicing: named isoforms=2 Primarily expressed in brain
General
adhesion receptor
glycoprotein
Properties
SIZE: MW = 222 kD
entity length = 2012 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
N-glycosylation site {N28}
immunoglobulin superfamily domain {39-129}
MOTIF: cysteine residue {C46}
MODIFICATION: cysteine residue {C102}
N-glycosylation site {N78}
cysteine residue {C102}
MODIFICATION: cysteine residue {C46}
immunoglobulin superfamily domain {125-216}
MOTIF: cysteine residue {C145}
MODIFICATION: cysteine residue {C197}
cysteine residue {C197}
MODIFICATION: cysteine residue {C145}
immunoglobulin superfamily domain {225-305}
MOTIF: cysteine residue {C246}
MODIFICATION: cysteine residue {C293}
cysteine residue {C293}
MODIFICATION: cysteine residue {C246}
immunoglobulin superfamily domain {313-401}
MOTIF: cysteine residue {C335}
MODIFICATION: cysteine residue {C385}
cysteine residue {C385}
MODIFICATION: cysteine residue {C335}
immunoglobulin superfamily domain {407-500}
MOTIF: cysteine residue {C428}
MODIFICATION: cysteine residue {C484}
N-glycosylation site {N470}
cysteine residue {C484}
MODIFICATION: cysteine residue {C428}
N-glycosylation site {N487}
immunoglobulin superfamily domain {504-592}
MOTIF: N-glycosylation site {N512}
cysteine residue {C525}
MODIFICATION: cysteine residue {C575}
N-glycosylation site {N556}
cysteine residue {C575}
MODIFICATION: cysteine residue {C525}
immunoglobulin superfamily domain {596-685}
MOTIF: cysteine residue {C617}
MODIFICATION: cysteine residue {C669}
N-glycosylation site {N658}
N-glycosylation site {N666}
cysteine residue {C669}
MODIFICATION: cysteine residue {C617}
immunoglobulin superfamily domain {690-783}
MOTIF: N-glycosylation site {N710}
cysteine residue {C711}
MODIFICATION: cysteine residue {C766}
N-glycosylation site {N748}
cysteine residue {C766}
MODIFICATION: cysteine residue {C711}
immunoglobulin superfamily domain {787-883}
MOTIF: N-glycosylation site {N795}
cysteine residue {C809}
MODIFICATION: cysteine residue {C865}
cysteine residue {C865}
MODIFICATION: cysteine residue {C809}
fibronectin type III domain or F3 module {885-978}
MOTIF: N-glycosylation site {N924}
fibronectin type III domain or F3 module {984-1082}
fibronectin type III domain or F3 module {1088-1183}
MOTIF: N-glycosylation site {N1142}
N-glycosylation site {N1160}
fibronectin type III domain or F3 module {1189-1279}
MOTIF: N-glycosylation site {N1250}
N-glycosylation site {N1271}
immunoglobulin superfamily domain {1285-1377}
MOTIF: cysteine residue {C1307}
MODIFICATION: cysteine residue {C1359}
N-glycosylation site {N1341}
cysteine residue {C1359}
MODIFICATION: cysteine residue {C1307}
fibronectin type III domain or F3 module {1376-1470}
fibronectin type III domain or F3 module {1476-1566}
MOTIF: N-glycosylation site {N1488}
transmembrane domain {1596-1616}
Database Correlations
OMIM 602523
UniProt O60469
PFAM correlations
References
UniProt :accession O60469