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down-regulated in metastasis protein; small subunit processome component 20 homolog; novel nucleolar protein 73; NNP73; protein key-1A6 (UTP20 DRIM)
Function:
- role in 18S pre-rRNA processing
- associates with U3 snoRNA
- interacts with FBL & PPP1R26
Structure:
- belongs to the UTP20 family
- contains 2 HEAT repeats
Compartment:
- nucleus, nucleolus
- colocalizes with NCL in the nucleolus
Expression:
- expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis & thymus
Related
metastasis
General
HEAT repeat-containing protein (HEATR)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 2785 aa
MW = 318 kD
COMPARTMENT: cell nucleus
MOTIF: HEAT repeat {165-202}
Ser phosphorylation site {S788}
lysine-rich region {1319-1324}
MOTIF: lysine residue (SEVERAL)
Thr phosphorylation site {T1741}
HEAT repeat {1841-1878}
Thr phosphorylation site {T2064}
Ser phosphorylation site {S2601}
Ser phosphorylation site {S2637}
coiled coil {2688-2765}
nuclear translocation signal {2744-2775}
MOTIF: Nucleolar localization signal {2744-2761}
Database Correlations
OMIM 612822
UniProt O75691
Pfam PF07539
Entrez Gene 27340
Kegg hsa:27340
References
UniProt :accession O75691