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double-stranded RNA-specific editase B2; RNA-dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; dsRNA adenosine deaminase B2 (ADARB2, ADAR3, RED2)
Function:
- does not act on glutamate receptor or on serotonin receptor 2C
- apable of binding to dsRNA, but also to ssRNA
Structure:
- contains 1 A to I editase domain
- contains 2 DRBM (double-stranded RNA-binding) domains
Compartment: nucleus
Expression: brain specific
General
metalloprotein
nuclear protein
nucleoside deaminase
Properties
SIZE: entity length = 739 aa
MW = 81 kD
COMPARTMENT: cell nucleus
MOTIF: DRBM 1 {125-191}
DRBM 2 {274-341}
A to I editase {408-735}
MOTIF: Zn+2-binding site
SITE: 432-432
glutamate residue {E434}
Zn+2-binding site
SITE: 490-490
Zn+2-binding site
SITE: 555-555
Database Correlations
OMIM 602065
UniProt Q9NS39
PFAM correlations
Entrez Gene 105
Kegg hsa:105
References
UniProt :accession Q9NS39