double-stranded RNA-binding protein Staufen homolog 2 (STAU2)

Function: 1) RNA-binding protein - DRBM 3 domain major RNA-binding motif 2) microtubule-dependent transport of neuronal RNA from perikarya to dendrite 3) localization of specific mRNAs to dendrites as prerequisite for neurite outgrowth & plasticity 4) interacts with exportin XPO5 via DRBM 3 domain, requires RNA & RAN bound to GTP 5) interacts with microtubules 6) isoforms 2 & 3 may also interact with ribosomes, independent of translation Structure: - contains 4 DRBM domains (double-stranded RNA-binding domains) Compartment: - cytoplasm, nucleus, nucleolus - shuttles between nucleolus, nucleus & cytoplasm - nuclear export of isoform 1 is independent of XPO1/CRM1 & requires exportin XPO - nuclear export of isoform 2 & 3 can occur by both XPO1/CRM1- dependent & XPO1/CRM1-independent pathways - found in large cytoplasmic ribonucleoprotein (RNP) granules present in the actin rich regions of myelinating processes - associated with microtubules, polysomes & endoplasmic reticulum - recruited to stress granules upon inhibition of translation or oxidative stress Alternative splicing: named isoforms=5

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 63 kD entity length = 570 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: DRBM 1 {8-75} DRBM 2 {95-181} DRBM 3 {207-274} nuclear translocation signal {273-291} DRBM 4 {307-375} nuclear translocation signal {373-412} dendritic transport {381-570} MOTIF: Ser phosphorylation site {S440}

Database Correlations

OMIM 605920 UniProt Q9NUL3 Pfam PF00035

References

UniProt :accession Q9NUL3