double-stranded RNA (dsRNA)

Most RNA is single stranded; however double-stranded forms occur. Function: - dsRNAs silence cognate genes through RNA interference Pathology: - TLR3 (CD283) mediates innate immune response to dsRNA of viral origin

References

Cerutti L., Mian N., Bateman A. Trends Biochem. Sci. 25:481-482(2000)