dothiepin (Prothiaden)

Tradename: Prothiaden Indications: -> depression Tabs: 75 mg Pharmacokinetics: 1) metabolized in liver to active metabolites a) dothiepin-S-oxide, dothiepin sulfoxide b) northiadin c) northiadin-S-oxide 2) a single 75 mg dose leads to mean serum level of 71 ng/mL 3) 1/2life 14-24 hours 4) decreased clearance in the elderly Adverse effects: 1) dry mouth 2) drowsiness 3) constipation 4) nausea/vomiting 5) diarrhea 6) dizziness 7) tremor 8) sweating 9) insomnia 10) blurred vision 11) weight gain 12) palpitations 13) hypotension 14) headache 15) arrhythmias (prolongation of the QT interval ?) Laboratory: 1) specimen: serum, plasma; collect at steady-state - dothiepin in serum/plasma 2) methods: HPLC, GLC, GC-MS

Interactions

drug interactions drug adverse effects (more general classes)

Properties

MISC-INFO: elimination route LIVER lifetime NIL +/- NIL

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995