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dopaminergic receptor antagonist
Adverse effects:
- acute effects [1]
- acute dystonia
- often involves neck, face, larynx or eye
- rapidly reversed with IV diphendydramine
- acute akathisia
- late-appearing persistent effects (tardive syndromes)
- tardive dyskinesia
- tardive dystonia
- often affects the face, neck, arms, trunk
- tardive akathisia [1]
- subacute or chronic
- drug-induced parkinsonism
- reversible with discontinuation of offending agent
- withdrawal syndromes
- dystonia resolves within a few months
- neuroleptic malignant syndrome
Notes:
- dopmine D2 receptor antagonist
Interactions
drug interactions
drug adverse effects (more general classes)
Related
dopamine receptor
Specific
chlorpromazine (Thorazine, Ormazine, Propaphenin, Sonazine, Chloractil)
clozapine (Clozaril)
droperidol (Inapsine)
fluphenazine (Prolixin, Anatensol, Triflumethazine, Calmansial, Modecate)
haloperidol (Haldol, Halperon, Aloperidol, Halomonth)
metoclopramide (Reglan, Metozolv ODT)
olanzapine (Zyprexa, Zydis, Zyprexa, Relprevv)
paliperidone (9-hydroxyrisperidone, Invega, Invega Sustenna)
prochlorperazine (Compazine, Stemetil, Novamin, Buccastem)
quetiapine (Seroquel)
risperidone (Risperdal)
sertindole (Serlect)
thioridazine (Mellaril, Millazine, Melleretten)
trifluoperazine (Stelazine, Suprazine)
General
adrenergic receptor antagonist
References
- Medical Knowledge Self Assessment Program (MKSAP) 16, 17
American College of Physicians, Philadelphia 2012, 2014