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L-dopachrome tautomerase; DCT; DT; L-dopachrome delta-isomerase; tyrosinase-related protein 2; TRP-2; TRP2 (DCT, TYRP2)
Function:
- role in regulating eumelanin & phaeomelanin levels
- tyrosinase, TYRP1 & TYRP2 may form a multienzyme complex (putative)
- pigment biosynthesis; melanin biosynthesis
L-dopachrome 5,6-dihydroxyindole-2-carboxylate
Cofactor: binds 2 Zn+2 per subunit (putative)
Structure: belongs to the tyrosinase family
Compartment: melanosome membrane
Related
D-dopachrome decarboxylase; D-dopachrome tautomerase; phenylpyruvate tautomerase 2 (DDT)
tyrosinase (monophenol monooxygenase, tumor rejection antigen AB, SK29-AB, LB24-AB, TYR)
General
glycoprotein
membrane protein
metalloprotein
oxidoreductase
Properties
SIZE: entity length = 519 aa
MW = 59 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
N-glycosylation site {N170}
N-glycosylation site {N178}
Zn+2-binding site
SITE: 189-189
Zn+2-binding site
SITE: 211-211
Zn+2-binding site
SITE: 220-220
N-glycosylation site {N237}
N-glycosylation site {N300}
N-glycosylation site {N342}
Zn+2-binding site
SITE: 369-369
Zn+2-binding site
SITE: 373-373
N-glycosylation site {N377}
Zn+2-binding site
SITE: 396-396
transmembrane domain {473-493}
Database Correlations
OMIM 191275
UniProt P40126
Pfam PF00264
Entrez Gene 1638
Kegg hsa:1638
ENZYME 5.3.3.12
References
UniProt :accession P40126