docking protein 6; downstream of tyrosine kinase 6 (DOK6, DOK5L)

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses. Function: - DOK6 promotes RET-mediated neurite growth - may have a role in brain development &/or maintenance - on Ret activation, phosphorylated on one or more C-terminal Tyr by an Src family kinase - interacts via its PTB domain with phosphorylated RET Structure: - PTB domain mediates receptor interaction (putative) - belongs to the DOK family, type B subfamily - contains 1 IRS-type PTB domain - contains 1 PH domain Expression: - highly expressed in fetal & adult brain - highly expressed in the cerebellum - weak expression in kidney, spinal cord & testis.

General

docking protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 331 aa MW = 38 kD COMPARTMENT: cell nucleus MOTIF: PH domain {8-112} phosphorylation site phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 132-237 DKFBH {263-273}

Database Correlations

OMIM 611402 UniProt Q6PKX4 PFAM correlations Entrez Gene 220164 Kegg hsa:220164

References

UniProt :accession Q6PKX4