docking protein 4; downstream of tyrosine kinase 4; insulin receptor substrate 5; IRS-5; IRS5 (DOK4)

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses. Function: 1) RET-mediated neurite outgrowth 2) activation of the MAP kinase pathway 3) regulation of the immune response induced by T-cells 4) interaction with RET a) mediated through PTB domain b) requires phosphorylation of RET Tyr-1062 5) link with downstream effectors of RET in neuronal differentiation 6) may be involved in the regulation of the immune response induced by T-cells 7) interaction with TEK 8) phosphorylated on Tyr in response to insulin, IGF1 or RET stimulation Structure: - PTB domain mediates receptor interaction (putative) - belongs to the DOK family, type B subfamily - contains 1 IRS-type PTB domain - contains 1 PH domain Expression: - widely expressed - high expression in skeletal muscle, heart, kidney & liver - expressed in both resting &activated peripheral blood T-cells

General

docking protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 326 aa MW = 37 kD COMPARTMENT: cell nucleus MOTIF: PH domain {7-112} phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 132-237 DKFBH {265-275}

Database Correlations

OMIM 608333 UniProt Q8TEW6 PFAM correlations Entrez Gene 55715 Kegg hsa:55715

References

UniProt :accession Q8TEW6