docking protein 3; downstream of tyrosine kinase 3 (DOK3)

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses. Function: - negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1 - may modulate ABL1 function - constitutively Tyr-phosphorylated (putative) - on IL2 stimulation, phosphorylated on C-terminal Tyr possibly by Src kinases - can also be phosphorylated by ABL1 kinase (putative) - on Tyr phosphorylation, interacts with CSK & INPP5D/SHIP1 via their SH2 domains - both Tyr-381 & Tyr-398 are required for interaction with INPP5D - only Tyr-381 is required for interaction with CSK - binds ABL1 through the PTB domain (kinase-dependent) - does not interact with RasGAP Structure: - PTB domain mediates receptor interaction (putative) - belongs to the DOK family, type A subfamily - contains 1 IRS-type PTB domain - contains 1 PH domain Compartment: - cytoplasm (putative) - cell membrane, cytoplasmic side (putative) Alternative splicing: named isoforms=4 Expression: expressed in spleen

General

docking protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 496 aa MW = 53 kD COMPARTMENT: cytoplasm MOTIF: PH domain {63-179} phosphotyrosine interaction domain NAME: phosphotyrosine interaction domain SITE: 213-317 proline-rich region SITE: 320-373 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S330} Tyr phosphorylation site {Y381} proline-rich region SITE: 391-496 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 611435 UniProt Q7L591 Pfam PF02174 Entrez Gene 79930 Kegg hsa:79930

References

UniProt :accession Q7L591