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DNA repair-scaffolding protein; scaffolding protein involved in DNA repair (SPIDR, KIAA0146)
Function:
- role in DNA double-strand break repair via homologous recombination
- serves as a scaffolding protein that helps promote recruitment of DNA-processing enzymes like the helicase BLM & recombinase RAD51 to site of DNA damage
- found in a complex, at least composed of BLM, RAD51 & SPIDR
- complex formation is mediated by SPIDR
- interacts (via C-terminus region) with BLM
- interacts with RAD51
- interacts (via the C-terminus region) with FIGNL1 (via N-terminus one-half region)
Compartment:
- nucleus
- together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea or camptothecin treatment
Expression:
- up-regulated in vascular endothelial cells treated with IL4
- up-regulated upon human SARS coronavirus infection
General
nuclear protein
Properties
SIZE: entity length = 915 aa
MW = 100 kD
COMPARTMENT: cell nucleus
MOTIF: Necessary for interaction with RAD51 {151-450}
Database Correlations
OMIM 615384
UniProt Q14159
PFAM correlations
Entrez Gene 23514
Kegg hsa:23514
References
UniProt :accession Q14159