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DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 (XRCC3)
Function:
- role in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations & deletions
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with RAD51C & RAD51. part of a complex
- consisting of RAD51B, RAD51C, RAD51D, XRCC2 & XRCC3
Structure: belongs to the recA family, RAD51 subfamily
Compartment: nucleus (probable)
Pathology:
- Met-241 is associated with the development of cutaneous malignant melanoma
Related
X-ray repair, complementing defective, repair in Chinese hamster cells-3 (XRCC3) gene
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 346 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 107-114
Ser phosphorylation site {S225}
References
- UniProt :accession O43542
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/XRCC3ID335ch14q32.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/xrcc3/
Component-of
BCDX2 complex
Databases & Figures
OMIM 600675
MORBIDMAP 600675
UniProt O43542
Pfam PF08423
Entrez Gene 7517
Kegg hsa:7517
Double strand break repair: homologous recombination